Heisenberg uncertainty in measurement
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The whole science of thermodynamics that you've learned is basically trying to quantify these energies. The highest strength chemical bonds are just a little over three electron volts for carbon or silicon-oxygen. You've got other bonds that are down around one electron volt. These are the energy for the primary bonds. You have secondary bonds that are ten times weaker. So when you're trying to measure something, you have to worry about whether you're going to do something to change the material. Remember Heisenberg said: you try to measure the position of something and you hit it with a photon, and if you're talking about quantum mechanical things, that photon is going to move the thing so the position changes — and that leads to the Heisenberg uncertainty principle.